Medical Use
Prevymis is a CMV DNA terminase complex inhibitor used to prevent cytomegalovirus (CMV) infection and disease in adult CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant (HSCT).
Recommended Dosage:
- -Prevymis Tablets: Can be taken with or without food. Swallow the tablets whole.
- -Prevymis Injection: Administered by intravenous infusion through a peripheral catheter or central venous line over 1 hour. Do not give as an intravenous bolus injection.
The recommended dosage is 480 mg, taken orally or intravenously once daily. Start treatment between Day 0 and Day 28 post-transplantation (before or after engraftment) and continue until Day 100 post-transplantation.
Use Prevymis injection, which contains hydroxypropyl betadex, only for patients who cannot take oral medication. Switch to oral Prevymis as soon as possible. Both the injection and tablet forms can be used interchangeably without dosage adjustment, based on the healthcare provider’s discretion.
Dosage Adjustments with Cyclosporine:
- -If Prevymis is taken with cyclosporine, reduce the Prevymis dose to 240 mg once daily.
- -If cyclosporine is started after Prevymis, reduce the next Prevymis dose to 240 mg once daily.
- -If cyclosporine is stopped after Prevymis, increase the next Prevymis dose to 480 mg once daily.
- -If cyclosporine dosing is temporarily interrupted due to high levels, no adjustment to the Prevymis dose is needed.
Warning & Precautions
Renal Impairment:
- -For patients with creatinine clearance (CLcr) above 10 mL/min, no dose adjustment of Prevymis 240 mg is necessary due to renal impairment.
- -For those with CLcr below 50 mL/min receiving the injection, there may be an accumulation of the intravenous vehicle, hydroxypropyl betadex. Monitor serum creatinine levels closely in these patients.
Hepatic Impairment:
- -No dosage adjustment is needed for patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment.
- -Prevymis is not recommended for patients with severe (Child-Pugh Class C) hepatic impairment.
Drug Interactions:
- -Concomitant use of Prevymis 480 mg tablets with certain drugs can lead to significant interactions, potentially causing side effects or reducing the effectiveness of Prevymis or the other medications.
- -Use Letermovir cautiously with CYP3A substrates that have narrow therapeutic ranges (e.g., fentanyl, alfentanil, quinidine) as it may increase their plasma concentrations. Precise monitoring or dose adjustments of these co-administered drugs are necessary.
- -Letermovir is a moderate inducer of transporters and enzymes, which can reduce the plasma concentrations of some drugs. Therapeutic drug monitoring (TDM) is needed for voriconazole. Avoid using dabigatran concurrently due to the risk of reduced efficacy.
Monitoring Requirements:
- -Increased monitoring of tacrolimus, cyclosporine, and sirolimus is generally required during the first few weeks after starting or stopping Letermovir 240 mg, as well as after changing its route of administration.
Special Considerations:
- -Prevymis contains lactose monohydrate. Patients with rare hereditary conditions like galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption should avoid this medication.
- -This medication contains less than 1 mmol sodium (23 mg) per tablet, essentially making it ‘sodium-free’.
Pregnancy and Breastfeeding:
- -Letermovir is not recommended during pregnancy, breastfeeding, or for women of childbearing age not using contraception. It is unknown if this medication is excreted in breast milk, so a risk to newborns and infants cannot be excluded.
Documentation Availability
Documents required to import PREVYMIS to India?
PREVYMIS (Letermovir) injection/tablet can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing PREVYMIS (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the Generic Name for Prevymis®?
The generic name for the trade name drug Prevymis® is Letermovir.
Who Manufactures Prevymis®?
Prevymis® is manufactured by Merck.
Is Prevymis® FDA Approved?
Yes, Prevymis® received FDA approval on November 8, 2017.
Where Can I Get Prevymis® at the Best Price in India?
For the best price on Prevymis (Letermovir) in India, contact Rx4u team.
What is the Dosage and Form of Prevymis®?
Prevymis® is available in the following forms:
- Tablets: 240 mg and 480 mg
- Injection: 240 mg/12 mL (20 mg/mL) and 480 mg/24 mL (20 mg/mL) in single-dose vials
What are the Most Common Side Effects of Prevymis®?
Common side effects include cough, nausea, diarrhea, peripheral edema, headache, vomiting, fatigue, and abdominal pain.
How Much Does Prevymis® Cost in India?
The cost of Prevymis in India is relatively affordable and may vary. For authentic procurement, you can reach out to Rx4u team.
What are the Storage Conditions for Prevymis®?
Store Prevymis tablets and injections at 20°C to 25°C (68°F to 77°F), with allowable excursions to 15°C to 30°C (59°F to 86°F). Keep tablets in their original packaging until use and store injections in their original carton to protect from light.
Is it Safe to Buy Prevymis® Online from India?
Yes, you can safely purchase Prevymis® online in India through https://rx4u.in/.
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